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dss plus epptb  (MedChemExpress)


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    MedChemExpress dss plus epptb
    Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
    Dss Plus Epptb, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dss+plus+epptb/Ro+5212773/pmc12808517-52-26-31
    Average 94 stars, based on 2 article reviews
    dss plus epptb - by Bioz Stars, 2026-09
    94/100 stars

    Images

    1) Product Images from "The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition"

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition

    Journal: Biochemistry and Biophysics Reports

    doi: 10.1016/j.bbrep.2025.102432

    Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
    Figure Legend Snippet: Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

    Techniques Used: Inhibition, Ex Vivo, Control

    Related Articles

    Inhibition:

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition
    Article Snippet: The experimental timeline spanned from day 13 to day 29 (final day).The experimental timeline spanned from day 13 to day 29 (final day).. Following one cycle of DSS administration, all mice developed consistent colitis and were randomly allocated into two groups (n = 6 per group): DSS alone, and DSS plus EPPTB (10 mg/kg; MedChemExpress, New Jersey, USA).. Both groups exhibited comparable baseline colitis severity and similar daily water consumption.Both groups exhibited comparable baseline colitis severity and similar daily water consumption.

    Ex Vivo:

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition
    Article Snippet: The experimental timeline spanned from day 13 to day 29 (final day).The experimental timeline spanned from day 13 to day 29 (final day).. Following one cycle of DSS administration, all mice developed consistent colitis and were randomly allocated into two groups (n = 6 per group): DSS alone, and DSS plus EPPTB (10 mg/kg; MedChemExpress, New Jersey, USA).. Both groups exhibited comparable baseline colitis severity and similar daily water consumption.Both groups exhibited comparable baseline colitis severity and similar daily water consumption.

    Control:

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition
    Article Snippet: The experimental timeline spanned from day 13 to day 29 (final day).The experimental timeline spanned from day 13 to day 29 (final day).. Following one cycle of DSS administration, all mice developed consistent colitis and were randomly allocated into two groups (n = 6 per group): DSS alone, and DSS plus EPPTB (10 mg/kg; MedChemExpress, New Jersey, USA).. Both groups exhibited comparable baseline colitis severity and similar daily water consumption.Both groups exhibited comparable baseline colitis severity and similar daily water consumption.



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    dss plus epptb  (MedChemExpress)
    94
    MedChemExpress dss plus epptb
    Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
    Dss Plus Epptb, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dss+plus+epptb/Ro+5212773/pmc12808517-52-26-31
    Average 94 stars, based on 1 article reviews
    dss plus epptb - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

    Journal: Biochemistry and Biophysics Reports

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition

    doi: 10.1016/j.bbrep.2025.102432

    Figure Lengend Snippet: Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

    Article Snippet: Following one cycle of DSS administration, all mice developed consistent colitis and were randomly allocated into two groups (n = 6 per group): DSS alone, and DSS plus EPPTB (10 mg/kg; MedChemExpress, New Jersey, USA).

    Techniques: Inhibition, Ex Vivo, Control